Cytarabine and Its Neurological Side Effects

Academic Anxiety?

Get an original paper within hours and nail the task

156 experts online

Cytarabine and Its Neurological Side Effects

Words: 342

Subject: Pharmacology

Table of Contents Name of the Drug Type of the Drug Medical Use Methods of Application Relevance Side Effects Handling risks References Name of the Drug Cytarabine, also known as Ara-C and Arabinosylcytosine.

We will write a custom Cytarabine and Its Neurological Side Effects specifically for you for only $14.00 $11,90/page

308 certified writers online

Learn More

Type of the Drug It is an antineoplastic, cytotoxic (anti-cancer) medicine. Medical Use Its primary purpose is treatment of leukemia and its different forms, which include acute lymphocitic leukemia, and acute and chronic forms of myelogenous leukemia. The drug is also used on forms of cancer found in the in the brain and spinal cord (ordinary and meningeal lymphoma, as well as meningeal leukemia). Finally, Cytarabine has antiviral effects, but its usefulness in this area is limited by its lack of selectiveness. Methods of Application It is applied to the patient by an intravenous or IV infusion, injection into the subcutaneous tissues (separating the skin and the muscle), and by intranthecal or intraventricular infusion, when the medicine needs to be applied to the cerebrospinal fluid around the brain and the spinal cord. Relevance This drug is on the World Health Organization’s List of Essential Medicines, because of its effectiveness in cancer treatment. High doses of Cytarabine have demonstrated very impressive results in the cancer treatment in patients who are resistant to conventional doses. It has few alternatives, and yet side effects are very dangerous, and warrant concern and study. Side Effects Between 7% to 28% of patients have reported severe cerebellar and cerebral dysfunction side effects associated with the high-dose consumption of the drug. The effects of neurologic toxicity are very serious and can lead to life-threatening complications.

Get your 100% original paper on any topic done in as little as 3 hours

Learn More

These complications were observed by Kerry Nichols in Billings Clinic Hospital, who estimated that high-dose of the drug was administered to 20-25 patients annually. She observed one of the patients develop symptoms such as unsteady walk and shaking hands, and continuous functional decline, to the point of full functional dependency (Dantoni, 2013). Handling risks To prevent serious complications and manage toxicity levels, Nichols developed a number of procedures. The first of these was the neurologic assessment tool, which combined a variety of tests designed to assess cerebellar toxicity. These were supported with a double-check system, upheld by two Rheumatology Nurses certified for chemotherapy. References Dantoni, T. (2013). High Dose Cytarabine Neurological Assessment Guide Streamlines Symptom Documentation. Web.

Need an essay written specifically to meet your requirements?

Choose skilled experts on your subject and get an original paper within your deadline

156 experts online

Your time is important. Let us write you an essay from scratch

Tips and Tricks from our Blog

11174 Introduction To Management

Free Samples 11174 Introduction To Management .cms-body-content table{width:100%!important;} #subhidecontent{ position: relative; overflow-x: auto; width: 100%;} 11174 Introduction

Read More »